HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 291/3/E574    most recent 00068.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Gelegen, C. Articles by Kas, M. J. H. Search for Related Content PubMed PubMed Citation Articles by Gelegen, C. Articles by Kas, M. J. H.

Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains

¹Department of Pharmacology and Anatomy, Behavioural Genomics Section, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands; King's College Institute of ³Psychiatry and ²Social, Genetic, and Developmental Psychiatry Research Centre, London, United Kingdom

Submitted 8 February 2006 ; accepted in final form 27 April 2006

Food restriction paradigms are widely used in animal studies to investigate systems involved in energy regulation. We have observed behavioral, physiological, and molecular differences in response to food restriction in three inbred mouse strains, C57BL/6J, A/J, and DBA/2J. These are the progenitors of chromosome substitution and recombinant inbred mouse strains used for mapping complex traits. DBA/2J and A/J mice increased their locomotor activity during food restriction, and both displayed a decrease in body temperature, but the decrease was significantly larger in DBA/2J compared with A/J mice. C57BL/6J mice did not increase their locomotor activity and displayed a large decrease in their body temperature. The large decline in body temperature during food restriction in DBA/2J and C57BL/6J strains was associated with a robust reduction in plasma leptin levels. DBA/2J mice showed a marked decrease in white and brown adipose tissue masses and an upregulation of the antithermogenic hypothalamic neuropeptide Y Y₁ receptor. In contrast, A/J mice showed a reduction in body temperature to a lesser extent that may be explained by downregulation of the thermogenic melanocortin 3 receptor and by behavioral thermoregulation as a consequence of their increased locomotor activity. These data indicate that genetic background is an important parameter in controlling an animal's adaptation strategy in response to food restriction. Therefore, mouse genetic mapping populations based on these progenitor lines are highly valuable for investigating mechanisms underlying strain-dependent differences in behavioral physiology that are seen during reduced food availability.

locomotor activity; body temperature; food intake; neuropeptide Y; melanocortin

This article has been cited by other articles:

				R. Gutman, R. Hacmon-Keren, I. Choshniak, and N. Kronfeld-Schor Effect of food availability and leptin on the physiology and hypothalamic gene expression of the golden spiny mouse: a desert rodent that does not hoard food Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R2015 - R2023. [Abstract] [Full Text] [PDF]

				V. Kus, T. Prazak, P. Brauner, M. Hensler, O. Kuda, P. Flachs, P. Janovska, D. Medrikova, M. Rossmeisl, Z. Jilkova, et al. Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E356 - E367. [Abstract] [Full Text] [PDF]

				L. M. Vaanholt, B. De Jong, T. Garland Jr, S. Daan, and G. H. Visser Behavioural and physiological responses to increased foraging effort in male mice J. Exp. Biol., June 1, 2007; 210(11): 2013 - 2024. [Abstract] [Full Text] [PDF]