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Am J Physiol Endocrinol Metab 289: E2-E7, 2005. First published March 1, 2005; doi:10.1152/ajpendo.00274.2004
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Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans

N. Hiscock,1,2,3 C. P. Fischer,1,2 M. Sacchetti,1 G. van Hall,1 M. A. Febbraio,3 and B. K. Pedersen1,2

1The Copenhagen Muscle Research Center; 2Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; and 3Royal Melbourne Institute of Technology University, School of Medical Sciences, Bundoora, Victoria, Australia

Submitted 23 June 2004 ; accepted in final form 6 December 2004

The present study examined the role of the cytokine IL-6 in the regulation of fatty acid metabolism during exercise in humans. Six well-trained males completed three trials of 120 min of cycle ergometry at 70% peak O2 consumption (O2 peak; MOD) and 40% O2 peak with (LOW + IL-6) and without (LOW) infusion of recombinant human (rh)IL-6. The dose of rhIL-6 during LOW + IL-6 elicited IL-6 concentration similar to those during MOD but without altering the circulating hormonal milieu seen in MOD. Palmitate rate of appearance (Ra), rate of disappearance (Rd), and oxidation were measured by means of a constant infusion of [U-13C]palmitate (0.015 µmol·kg–1·min–1, prime NaHCO3, 1 µmol/kg). Palmitate Ra, Rd, and oxidation were not affected by rhIL-6 infusion, remaining similar to LOW at all times. Palmitate Ra and oxidation were significantly greater in the MOD trial (P < 0.05) compared with the LOW + IL-6 and LOW trials. Our data show that a low dose of rhIL-6, administered during low-intensity exercise without altering the hormonal milieu, does not alter fatty acid metabolism. These data suggest that the increase in fatty acid utilization seen during exercise at moderate compared with low intensity is not mediated via alterations in plasma IL-6.

cytokine; metabolism


Address for reprint requests and other correspondence: N. Hiscock, Corporate Research, Unilever R&D, Sharnbrook, Bedfordshire, MK44 1LQ, United Kingdom (e-mail: natalie.hiscock{at}unilever.com)




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