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Am J Physiol Endocrinol Metab 282: E147-E153, 2002;
0193-1849/02 $5.00
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Vol. 282, Issue 1, E147-E153, January 2002

Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men

Charles J. Tanner1,2, Timothy R. Koves3, Ronald L. Cortright1,2,3, Walter J. Pories3, Young-Bum Kim4, Barbara B. Kahn4, G. Lynis Dohm1,3, and Joseph A. Houmard1,2

1 Human Performance Laboratory, Diabetes/Obesity Center, and 2 Departments of Exercise and Sport Science, and 3 Biochemistry, Medicine, Physiology, and Surgery, East Carolina University, Greenville, North Carolina 27858; and 4 Diabetes Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215

The purpose of this study was to determine whether the improved insulin action with short-term exercise training in middle-aged individuals is associated with enhanced phosphatidylinositol (PI) 3-kinase activity in skeletal muscle. Nine men of ages 50-70 yr were studied before and after 7 consecutive days of supervised exercise (60 min/day, 70% peak O2 consumption). Insulin sensitivity was measured with a euglycemic hyperinsulinemic glucose clamp in the sedentary condition and 15-17 h after the final exercise session. Anti-phosphotyrosine-associated PI 3-kinase activity was determined from muscle samples obtained in the fasted condition and after 60 min of insulin infusion during the clamp. With exercise, the glucose infusion rate increased (P < 0.001) by 33%, indicating enhanced insulin action (mean ± SE, 6.6 ± 0.6 vs. 8.7 ± 0.8 mg · kg-1 · min-1). Short-term exercise training did not, however, increase insulin-stimulated (insulin stimulated/fasting) PI 3-kinase activity (1.8 ± 0.8 vs. 1.8 ± 0.7-fold stimulation with insulin pre- vs. posttraining, respectively). There was also no change in insulin-stimulated protein kinase B activity (1.3 ± 0.1 vs. 1.4 ± 0.2-fold stimulation with insulin) with training. These data suggest that insulin action is enhanced with short-term exercise training via an adaptation distal to PI 3-kinase in middle-aged, insulin-resistant individuals.

aging; glucose transport; insulin resistance; physical activity; skeletal muscle


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