| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Human Performance Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas 78712
We determined whether a low-fat
diet reduces intramuscular triglyceride (IMTG) concentration, whole
body lipolyis, total fat oxidation, and calculated nonplasma fatty acid
(FA) oxidation during exercise. Seven endurance-trained cyclists were
studied over a 3-wk period during which time they exercised 2 h/day at 70% of maximum O2 uptake
O2 max and consumed ~4,400 kcal/day. During the 1st wk, their fat intake provided 32% of energy. During the
2nd and 3rd wk, they were randomly assigned to eat 2 or 22% of energy
from fat (2%FAT or 22%FAT). Compared with 22%FAT, 2%FAT lowered
IMTG concentration and raised muscle glycogen concentration at rest
(P < 0.05). Metabolism was studied during 1 h of
exercise at 67% O2 max performed in
the fasted state. 2%FAT resulted in a 27% reduction
(P < 0.05) in total fat oxidation vs. 22%FAT without
altering the stable isotopically determined rates of plasma free fatty
acid or glucose disappearance. Therefore, 2%FAT reduced calculated
nonplasma FA oxidation by 40% in association with a 19% reduction in
whole body lipolysis while increasing calculated minimal muscle
glycogen oxidation compared with 22%FAT (all P < 0.05). In summary, an extremely low fat (2% of energy) and
high-carbohydrate diet lowers whole body lipolysis, total fat
oxidation, and nonplasma FA oxidation during exercise in the fasted
state in association with a reduced concentration of intramuscular triglyceride.
stable isotopes; lipid; carbohydrate; de novo lipogenesis; obesity
This article has been cited by other articles:
|
|
 |
|
  W. K. Yeo, S. J. Lessard, Z.-P. Chen, A. P. Garnham, L. M. Burke, D. A. Rivas, B. E. Kemp, and J. A. Hawley Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans J Appl Physiol, November 1, 2008; 105(5): 1519 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. De Bock, W. Derave, B. O. Eijnde, M. K. Hesselink, E. Koninckx, A. J. Rose, P. Schrauwen, A. Bonen, E. A. Richter, and P. Hespel Effect of training in the fasted state on metabolic responses during exercise with carbohydrate intake J Appl Physiol, April 1, 2008; 104(4): 1045 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Moro, S. Bajpeyi, and S. R. Smith Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E203 - E213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Devries, S. A. Lowther, A. W. Glover, M. J. Hamadeh, and M. A. Tarnopolsky IMCL area density, but not IMCL utilization, is higher in women during moderate-intensity endurance exercise, compared with men Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2336 - R2342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Stellingwerff, L. L. Spriet, M. J. Watt, N. E. Kimber, M. Hargreaves, J. A. Hawley, and L. M. Burke Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E380 - E388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kiens Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance Physiol Rev, January 1, 2006; 86(1): 205 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Hansson, M. Donsmark, C. Ling, P. Nevsten, M. Danfelter, J. L. Andersen, H. Galbo, and C. Holm Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null mice J. Lipid Res., December 1, 2005; 46(12): 2614 - 2623. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Martin, M. J. Quod, C. J. Gore, and E. F. Coyle Has Armstrong's cycle efficiency improved? J Appl Physiol, October 1, 2005; 99(4): 1628 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Venables, J. Achten, and A. E. Jeukendrup Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study J Appl Physiol, January 1, 2005; 98(1): 160 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. C. van Loon Use of intramuscular triacylglycerol as a substrate source during exercise in humans J Appl Physiol, October 1, 2004; 97(4): 1170 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Fox, A. E. Kaufman, and J. F. Horowitz Adding fat calories to meals after exercise does not alter glucose tolerance J Appl Physiol, July 1, 2004; 97(1): 11 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Achten, S. L. Halson, L. Moseley, M. P. Rayson, A. Casey, and A. E. Jeukendrup Higher dietary carbohydrate content during intensified running training results in better maintenance of performance and mood state J Appl Physiol, April 1, 2004; 96(4): 1331 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Stannard and N. A. Johnson Insulin resistance and elevated triglyceride in muscle: more important for survival than 'thrifty' genes? J. Physiol., February 1, 2004; 554(3): 595 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. W. Zderic, C. J. Davidson, S. Schenk, L. O. Byerley, and E. F. Coyle High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E217 - E225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Helge and F. Dela Effect of Training on Muscle Triacylglycerol and Structural Lipids: A Relation to Insulin Sensitivity? Diabetes, August 1, 2003; 52(8): 1881 - 1887. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Bravata, L. Sanders, J. Huang, H. M. Krumholz, I. Olkin, C. D. Gardner, and D. M. Bravata Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review JAMA, April 9, 2003; 289(14): 1837 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Johnson, S. R. Stannard, K. Mehalski, M. I. Trenell, T. Sachinwalla, C. H. Thompson, and M. W. Thompson Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability J Appl Physiol, April 1, 2003; 94(4): 1365 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Watt, G. J. F. Heigenhauser, and L. L. Spriet Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J Appl Physiol, October 1, 2002; 93(4): 1185 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Larson-Meyer, B. R. Newcomer, and G. R. Hunter Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E95 - E106. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
