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Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan
Erythropoietin (Epo) produced by the
kidney regulates erythropoiesis. Recent evidence suggests that Epo in
the cerebrum prevents neuron death and Epo in the uterus induces
estrogen (E2)-dependent uterine angiogenesis. To elucidate
how Epo expression is regulated in these tissues, ovariectomized mice
were given E2 and/or exposed to hypoxia, and the temporal
patterns of Epo mRNA levels were examined. Epo mRNA levels in the
kidney and cerebrum were elevated markedly within 4 h after
exposure to hypoxia. Although the elevated level of Epo mRNA in the
kidney decreased markedly within 8 h despite continuous hypoxia,
the high level in the cerebrum was sustained for 
24 h, indicating
that downregulation operates in the kidney but not in the brain.
E2 transiently induced Epo mRNA in the uterus but not in
the kidney and cerebrum. Interestingly, the uterine Epo mRNA was
hypoxia inducible only in the presence of E2. Thus Epo
expression appears to be regulated in a tissue-specific manner,
endorsing the tissue-specific functions of Epo.
estrogen; hypoxia; real-time polymerase chain reaction; angiogenesis; neuron survival
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