AJP - Endo AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 279: E221-E227, 2000;
0193-1849/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kalderon, B.
Right arrow Articles by Bar-Tana, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kalderon, B.
Right arrow Articles by Bar-Tana, J.
Vol. 279, Issue 1, E221-E227, July 2000

Fatty acid cycling in the fasting rat

Bella Kalderon, Nina Mayorek, Elliot Berry, Noam Zevit, and Jacob Bar-Tana

Department of Human Nutrition and Metabolism, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel

Adipose tissue lipolysis and fatty acid reesterification by liver and adipose tissue were investigated in rats fasted for 15 h under basal and calorigenic conditions. The fatty acid flux initiated by adipose fat lipolysis in the fasted rat is mostly futile and is characterized by reesterification of 57% of lipolyzed free fatty acid (FFA) back into adipose triglycerides (TG). About two-thirds of FFA reesterification are carried out before FFA release into plasma, whereas the rest consists of plasma FFA extracted by adipose tissue. Thirty-six percent of the fasting lipolytic flux is accounted for by oxidation of plasma FFA, whereas only a minor fraction is channeled into hepatic very low density lipoprotein-triglycerides (VLDL-TG). Total body calorigenesis induced by thyroid hormone treatment and liver-specific calorigenesis induced by treatment with beta ,beta '-tetramethylhexadecanedioic acid (Medica 16) are characterized by a 1.7- and 1.3-fold increase in FFA oxidation, respectively, maintained by a 1.5-fold increase in adipose fat lipolysis. Hepatic reesterification of plasma FFA into VLDL-TG is negligible under both calorigenic conditions. Hence, total body fatty acid metabolism is regulated by adipose tissue as both source and sink. The futile nature of fatty acid cycling allows for its fine tuning in response to metabolic demands.

adipose tissue; lipoproteins; stable isotopes; thyroid hormone; Medica 16


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
L. Magnoni, E. Vaillancourt, and J.-M. Weber
In vivo regulation of rainbow trout lipolysis by catecholamines
J. Exp. Biol., August 1, 2008; 211(15): 2460 - 2466.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
P. C. LaRosa, J. Miner, Y. Xia, Y. Zhou, S. Kachman, and M. E. Fromm
Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis
Physiol Genomics, November 21, 2006; 27(3): 282 - 294.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. Zimmermann, G. Haemmerle, E. M. Wagner, J. G. Strauss, D. Kratky, and R. Zechner
Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue
J. Lipid Res., November 1, 2003; 44(11): 2089 - 2099.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Kalderon, N. Mayorek, L. Ben-Yaacov, and J. Bar-Tana
Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo
Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E795 - E803.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. Lucas, G. Tavernier, C. Tiraby, A. Mairal, and D. Langin
Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis
J. Lipid Res., January 1, 2003; 44(1): 154 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
S. F. Bernard, C. Fayolle, J.-P. Robin, and R. Groscolas
Glycerol and NEFA kinetics in long-term fasting king penguins: phase II versus phase III
J. Exp. Biol., September 1, 2002; 205(17): 2745 - 2754.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. P. Reidy and J.-M. Weber
Accelerated substrate cycling: a new energy-wasting role for leptin in vivo
Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E312 - E317.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. B. McClelland, P. W. Hochachka, S. P. Reidy, and J.-M. Weber
High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exercise
Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E537 - E544.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online