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1 Nutrition humaine et physiologie intestinale, and 2 Laboratoire de Nutrition et Alimentation, Unité Institut National de la Recherche Agronomique, Institut National Agronomique Paris-Grignon, 75231 Paris Cédex 05, France
A linear 11-compartment model was developed to describe and simulate the postprandial distribution of dietary nitrogen. The values of its 15 constant diffusion coefficients were estimated from the experimental measurement of 15N nitrogen kinetics in the intestine, blood, and urine after the oral administration of 15N-labeled milk protein in humans. Model structure development, parameter estimation, and sensibility analysis were achieved using SAAM II and SIMUSOLV softwares. The model was validated at each stage of its development by testing successively its a priori and a posteriori identifiability. The model predicted that, 8 h after a meal, the dietary nitrogen retained in the body comprised 28% free amino acids and 72% protein, ~30% being recovered in the splanchnic bed vs. 70% in the peripheral area. Twelve hours after the meal, these values had decreased to 18 and 23% for the free amino acid fraction and splanchnic nitrogen, respectively. Such a model constitutes a useful, explanatory tool to describe the processes involved in the metabolic utilization of dietary proteins.
mathematical model; parameter estimation; kinetics; protein metabolism; optimization
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