AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 276: E358-E364, 1999;
0193-1849/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bryson, J. M.
Right arrow Articles by Cooney, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bryson, J. M.
Right arrow Articles by Cooney, G. J.
Vol. 276, Issue 2, E358-E364, February 1999

Plasma insulin rise precedes rise in ob mRNA expression and plasma leptin in gold thioglucose-obese mice

Janet M. Bryson, Jenny L. Phuyal, Deborah R. Proctor, Stephen C. Blair, Ian D. Caterson, and Gregory J. Cooney

Department of Endocrinology, Royal Prince Alfred Hospital, Department of Medicine and Human Nutrition Unit, Department of Biochemistry, University of Sydney, and Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, New South Wales 2006, Australia

Circulating leptin levels are strongly related to the degree of adiposity, with hyperleptinemia being associated with hyperinsulinemia. In the gold thioglucose-injected mouse (GTG), hyperinsulinemia is an early abnormality in the development of insulin resistance and obesity. In this study, hyperinsulinemia occurred 1 wk post-GTG [GTG, 199 ± 43; age-matched controls (CON), 53 ± 5 µU/ml; P < 0.001], with leptin levels not rising until 2 wk post-GTG (CON, 3.2 ± 0.3; GTG, 9.9 ± 1.7 ng/ml; P < 0.001) in parallel with increases in the size of different fat pads and increased expression of ob mRNA. The ratio of serum leptin to fat pad weight was significantly higher in GTG mice 12 wk postinjection. Starvation-induced reductions in serum leptin (50%), glucose (50%), and insulin (74%) were greater than decreases in fat pad weight (18%). Adrenalectomy decreased both adiposity and serum leptin within 1 wk in both CON and GTG and altered the serum leptin level-to-fat pad weight ratio in CON. Thus hyperinsulinemia preceded increased ob expression and hyperleptinemia, which occurred in parallel with increasing adiposity, consistent with the role of leptin as an indicator of energy supplies. Changes in hormonal and nutritional status may modify this relationship.

ob gene; adiposity; adrenalectomy; fasting


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. A. Shore
Obesity and asthma: lessons from animal models
J Appl Physiol, February 1, 2007; 102(2): 516 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. J. Richards, J. R. Porter, and F. Svec
Serum Leptin, Lipids, Free Fatty Acids, and Fat Pads in Long-Term Dehydroepiandrosterone-Treated Zucker Rats
Experimental Biology and Medicine, March 1, 2000; 223(3): 258 - 262.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bryson, J. L. Phuyal, V. Swan, and I. D. Caterson
Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E417 - E422.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online