AJP - Endocrinology and Metabolism, Vol 273, Issue 1 E149-E155, Copyright © 1997 by American Physiological Society

ARTICLES

Exercise blunts declines in lipolysis and fat oxidation after dietary-induced weight loss in obese older women

B. J. Nicklas, E. M. Rogus and A. P. Goldberg
Department of Medicine, University of Maryland, Baltimore, USA.

Weight loss (WL) by hypocaloric diet decreases adipocyte lipolysis and fat oxidation, adaptations that might predispose individuals to regain weight. Our hypothesis was that the addition of endurance exercise (EX) to dietary-induced WL (6 mo; 250-350 kcal/day deficit) would prevent declines in abdominal (ABD) and gluteal (GLT) adipocyte lipolysis and fat oxidation in obese older women. At baseline, the WL (n = 9) and WL+EX (n = 11) groups had similar body composition, fat distribution, aerobic fitness (VO2max), and resting fat metabolism. Reductions in body weight (WL = 11%, WL+EX = 8%), percent body fat, and intra-abdominal fat area with the interventions were similar in both groups, but VO2max increased (9%, P < 0.01) only in the WL+EX group. Basal and adrenergic receptor- and postreceptor-stimulated lipolysis in ABD and GLT adipocytes decreased (20-70%, P < 0.05) in the WL group but did not change in the WL+EX group. Fat oxidation decreased (38%, P < 0.05) in the WL group but not in the WL+EX group. The changes in fat oxidation and GLT lipolysis differed significantly between groups. Fat oxidation correlated positively with ABD and GLT adipocyte basal lipolysis at baseline (r = 0.45 and r = 0.53, P < 0.05), and the changes in fat oxidation with the interventions correlated positively with changes in ABD and GLT adipocyte basal lipolysis (r = 0.50 and r = 0.42. P < 0.05) in the entire group of women. These results indicate that exercise counteracts the decline in fat oxidation with WL, in part by maintaining adipocyte lipolytic responsiveness in some weight-reduced postmenopausal women.

This article has been cited by other articles:

				F. Amati, J. J. Dube, C. Shay, and B. H. Goodpaster Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation J Appl Physiol, September 1, 2008; 105(3): 825 - 831. [Abstract] [Full Text] [PDF]

				T. P. J. Solomon, S. N. Sistrun, R. K. Krishnan, L. F. Del Aguila, C. M. Marchetti, S. M. O'Carroll, V. B. O'Leary, and J. P. Kirwan Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults J Appl Physiol, May 1, 2008; 104(5): 1313 - 1319. [Abstract] [Full Text] [PDF]

				I. de Glisezinski, C. Moro, F. Pillard, F. Marion-Latard, I. Harant, M. Meste, M. Berlan, F. Crampes, and D. Riviere Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E984 - E990. [Abstract] [Full Text] [PDF]

				D. P. van Aggel-Leijssen, W. H. Saris, G. B Hul, and M. A van Baak Short-term effects of weight loss with or without low-intensity exercise training on fat metabolism in obese men Am. J. Clinical Nutrition, March 1, 2001; 73(3): 523 - 531. [Abstract] [Full Text] [PDF]

				N. A. Lynch, B. J. Nicklas, D. M. Berman, K. E. Dennis, and A. P. Goldberg Reductions in visceral fat during weight loss and walking are associated with improvements in {V}O2 max J Appl Physiol, January 1, 2001; 90(1): 99 - 104. [Abstract] [Full Text] [PDF]

				A. S Ryan, B. J Nicklas, D. M Berman, and K. E Dennis Dietary restriction and walking reduce fat deposition in the midthigh in obese older women Am. J. Clinical Nutrition, September 1, 2000; 72(3): 708 - 713. [Abstract] [Full Text] [PDF]

				I. De Glisezinski, F. Crampes, I. Harant, M. Berlan, J. Hejnova, D. Langin, D. Riviere, and V. Stich Endurance training changes in lipolytic responsiveness of obese adipose tissue Am J Physiol Endocrinol Metab, December 1, 1998; 275(6): E951 - E956. [Abstract] [Full Text] [PDF]