AJP - Endocrinology and Metabolism, Vol 266, Issue 3 E459-E466, Copyright © 1994 by American Physiological Society

ARTICLES

Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats

J. M. Barragan, R. E. Rodriguez and E. Blazquez
Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.

This study was designed to determine the effects of glucagon-like peptides (GLP) on arterial blood pressure and heart rate. Although glucagon caused a minimal effect and GLP-1-(1-37) produced a moderate increase of both systolic and diastolic blood pressure, GLP-1-(7-36) amide induced the greatest increases in both parameters. Systolic and diastolic blood pressure and heart rate values increased when doses of the peptides were increased. By contrast, GLP-2 did not modify either arterial blood pressure or heart rate values. To determine whether the effects of GLP-1-(7-36) amide were mediated through catecholamines, the rats were pretreated with reserpine, propranolol, or phentolamine before administration of the peptide. In these three experimental groups, GLP-1-(7-36) amide increases mean arterial blood pressure and heart rate to the same level or even greater than that observed in nonpretreated rats. These findings indicate that GLP-1-(7-36) amide significantly increases arterial blood pressure and heart rate and that these effects are not mediated through catecholamines.

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