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AJP - Endocrinology and Metabolism, Vol 262, Issue 1 E96-E99, Copyright © 1992 by American Physiological Society
ARTICLES |
E. P. Gomez-Sanchez, C. Fort and D. Thwaites
Research Division, James A. Haley Veterans Hospital, Tampa, Florida.
The development of hypertension in the S/JR rat is accelerated and exacerbated by a high salt consumption. It has been reported that the intracerebroventricular infusion of RU28318, a selective mineralocorticoid antagonist, at doses that are ineffective when administered subcutaneously, inhibits the development of the hypertension produced by the subcutaneous infusion of aldosterone or deoxycorticosterone in normotensive rats. RU28318 was continuously infused intracerebroventricularly or subcutaneously in Dahl S/JR rats before or after the onset of hypertension induced by a high-salt diet. The centrally infused mineralocorticoid antagonist inhibited the initiation of the increase in blood pressure, when the infusion was started concomitantly with the high-salt diet, and blocked its further increase in rats whose blood pressure had already become significantly elevated with 2 wk of a high-salt diet. The subcutaneously infused mineralocorticoid antagonist had no effect. These data serve to strengthen the hypothesis that the mineralocorticoid receptor in the brain is crucial to the genesis of certain forms of hypertension.
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E. P. Gomez-Sanchez, J. Samuel, G. Vergara, and N. Ahmad Effect of 3{beta}-hydroxysteroid dehydrogenase inhibition by trilostane on blood pressure in the Dahl salt-sensitive rat Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R389 - R393. [Abstract] [Full Text] [PDF]
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B. S. Huang, H. Wang, and F. H. H. Leenen Chronic central infusion of aldosterone leads to sympathetic hyperreactivity and hypertension in Dahl S but not Dahl R rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H517 - H524. [Abstract] [Full Text] [PDF]
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