AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 260: E379-E388, 1991;
0193-1849/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Farrell, P. A.
Right arrow Articles by Kampine, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Farrell, P. A.
Right arrow Articles by Kampine, J. P.

AJP - Endocrinology and Metabolism, Vol 260, Issue 3 E379-E388, Copyright © 1991 by American Physiological Society

ARTICLES

Naloxone augments muscle sympathetic nerve activity during isometric exercise in humans

P. A. Farrell, T. J. Ebert and J. P. Kampine
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.

The influence of an endogenous opioid peptide (EOP) antagonist (naloxone, 1.2 mg iv bolus) on muscle sympathetic nerve activity (MSNA, microneurography) was studied on 19 young male and female volunteers. Isometric handgrip, cold pressor test, and acute baroreceptor unloading with sodium nitroprusside (autonomic stresses) were carried out under two conditions, one group (n = 11) before (control responses) and after naloxone and another group (n = 8) before and after placebo saline. Monitored cardiovascular variables included heart rate, central venous pressure (jugular vein catheter), arterial blood pressure (radial artery catheter), circulating catecholamines, and forearm blood flow. At rest, cardiovascular variables and MSNA were not affected by either naloxone or saline. MSNA (total activity = burst frequency x burst amplitude/100 cardiac cycles) increased during isometric handgrip to a greater extent (30 +/- 6 vs. 16 +/- 5 arbitrary units) after naloxone compared with control trials (P less than 0.05). After naloxone, arterial systolic and diastolic blood pressures were higher during handgrip exercise. These augmented arterial pressures and MSNA responses were not evident during either the cold pressor test or the sodium nitroprusside stress. These data suggest that isometric muscle contraction elicits a sympathetic neural response that may be modified by EOP. This interaction is not evident during two other stresses, when sympathetic responses are equal to or greater than those provoked by isometric handgrip exercise.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. R. Carter, C. L. Sauder, and C. A. Ray
Effect of morphine on sympathetic nerve activity in humans
J Appl Physiol, November 1, 2002; 93(5): 1764 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Kienbaum, T. Heuter, M. C. Michel, N. Scherbaum, M. Gastpar, and J. Peters
Chronic {micro}-Opioid Receptor Stimulation in Humans Decreases Muscle Sympathetic Nerve Activity
Circulation, February 13, 2001; 103(6): 850 - 855.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. B. Cook, P. J. O'Connor, and C. A. Ray
Muscle pain perception and sympathetic nerve activity to exercise during opioid modulation
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1565 - R1573.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online