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Am J Physiol Endocrinol Metab 258: E673-E677, 1990;
0193-1849/90 $5.00
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AJP - Endocrinology and Metabolism, Vol 258, Issue 4 E673-E677, Copyright © 1990 by American Physiological Society

ARTICLES

Dehydroepiandrosterone reduces cancellous bone osteopenia in ovariectomized rats

R. T. Turner, E. T. Lifrak, M. Beckner, G. K. Wakley, K. S. Hannon and L. N. Parker
Department of Orthopedics, Mayo Clinic, Rochester, Minnesota 55905.

The effects of dehydroepiandrosterone (DHA) on cortical bone at the tibial diaphysis and cancellous bone at the tibial metaphysis were determined in intact and ovariectomized rats. Total plasma DHA was reduced at 10 and 16 wk after ovariectomy. Intact and ovariectomized rats were implanted monthly with controlled-release subcutaneous pellets containing 2.5 mg of DHA or placebo. Plasma DHA was elevated in DHA-treated intact rats and was near normal in hormone-treated ovariectomized rats. Ovariectomy resulted in severe cancellous bone osteopenia, which was reduced in DHA-treated animals. Cross-sectional and cortical areas were increased at the diaphysis in ovariectomized rats, and this was not altered by DHA treatment. Bone formation at the endosteal and periosteal surfaces of the tibial diaphysis was decreased 16 wk after ovariectomy, and DHA treatment appeared to antagonize these changes. We interpret these results as evidence that decreased peripheral DHA levels contribute to the skeletal changes in ovariectomized rats.


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C. K. Lea and A. M. Flanagan
Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat
Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E328 - E335.
[Abstract] [Full Text] [PDF]


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