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Am J Physiol Endocrinol Metab 258: E555-E561, 1990;
0193-1849/90 $5.00
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AJP - Endocrinology and Metabolism, Vol 258, Issue 4 E555-E561, Copyright © 1990 by American Physiological Society

ARTICLES

Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel

A. Spat, I. Balla, T. Balla, P. Enyedi, G. Hajnoczky and T. Rohacs
Department of Physiology, Semmelweis University Medical School, Budapest, Hungary.

Angiotensin-induced aldosterone production by superfused adrenal glomerulosa cells was potentiated by Ni2+ (0.1 mM), added either at the onset of stimulation with angiotensin II or 1 h later. Nickel did not influence the effect of adrenocorticotropic hormone or potassium on aldosterone production. Nickel failed to modify angiotensin-induced changes in phospholipid metabolism or the formation of inositol phosphates and slightly reduced the enhancement of 45Ca influx. Uptake of Ni2+ into glomerulosa cells was increased by depolarization in a dihydropyridine-insensitive manner. Because nickel selectively potentiates the sustained phase of the response to a calcium-mobilizing hormone, it may serve as a suitable tool in elucidating the signal transduction process during the sustained phase of stimulation.


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A. SPAT and L. HUNYADY
Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways
Physiol Rev, April 1, 2004; 84(2): 489 - 539.
[Abstract] [Full Text] [PDF]


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