AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 238: E499-E505, 1980;
0193-1849/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow A corrigendum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, M. T.
Right arrow Articles by Williams, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, M. T.
Right arrow Articles by Williams, M. A.

AJP - Endocrinology and Metabolism, Vol 238, Issue 5 499-E505, Copyright © 1980 by American Physiological Society

ARTICLES

Essential fatty acid deficiency and plasma triglyceride turnover in rats

M. T. Huang and M. A. Williams

Hepatic triglyceride secretion in essential fatty acid-deficient rats was examined by three separate techniques in an effort to resolve conflicting evidence on the question of whether essential fatty acid deficiency altered hepatic triglyceride secretion in vivo. First, plasma triglyceride turnover was measured by intravenous injection of [2-3H]glycerol trioleate. Equations of the kinetics were formulated based on a single, open pool model. Turnover rates and pool sizes of plasma triglyceride were calculated from these equations. Second, [2-3H]glycerol was injected, and apparent rate constants for plasma triglyceride secretion and clearance were calculated by kinetic analysis. Third, Triton WR-1339 was used to inhibit lipoprotein clearance from blood plasma, and rates of plasma triglyceride accumulation were measured. The results of these studies showed that the rate of hepatic triglyceride secretion was 2-3 times greater in essential fatty acid-deficient rats than in nondeficient controls. The increase in triglyceride secretion, as well as the higher level of liver triglyceride typical of essential fatty acid-deficient rats, could be caused by increased lipogenesis and increased mobilization of fatty acids from adipose tissues.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Werner, R. Havinga, T. Bos, V. W. Bloks, F. Kuipers, and H. J. Verkade
Essential fatty acid deficiency in mice is associated with hepatic steatosis and secretion of large VLDL particles
Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1150 - G1158.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H.-M. Shaw and C.-j. Huang
Secretion of {{alpha}}-Tocopherol in VLDL Is Decreased by Dietary Protein Insufficiency in Young Growing Rats
J. Nutr., December 1, 2000; 130(12): 3050 - 3054.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online